Promoter Polymorphisms in the Plasma Glutathione Peroxidase ( GPx-3 ) Gene
نویسندگان
چکیده
منابع مشابه
Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis.
BACKGROUND AND PURPOSE Plasma glutathione peroxidase (GPx-3) is a major antioxidant enzyme in plasma and the extracellular space that scavenges reactive oxygen species produced during normal metabolism or after oxidative insult. A deficiency of this enzyme increases extracellular oxidant stress, promotes platelet activation, and may promote oxidative posttranslational modification of fibrinogen...
متن کاملDeterminants of human plasma glutathione peroxidase (GPx-3) expression.
Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. GPx-3 deficiency has been associated with cardiovascular disease and stroke. The regulation of GPx-3 expression remains largely uncharacterized, however, and we studied its transcriptional and translational determinants in a cultured cell system. In transient transfections of a renal cell l...
متن کاملPromoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children.
BACKGROUND AND PURPOSE Plasma glutathione peroxidase (GPx-3)-deficiency increases extracellular oxidant stress, decreases bioavailable nitric oxide, and promotes platelet activation. The aim of this study is to identify polymorphisms in the GPx-3 gene, examine their relationship to arterial ischemic stroke (AIS) in a large series of children and young adults, and determine their functional mole...
متن کاملNo association of the plasma glutathione peroxidase (GPx-3) gene with cerebral venous thrombosis in the German population.
No Association of the Plasma Glutathione Peroxidase (GPx-3) Gene With Cerebral Venous Thrombosis in the German Population To the Editor: In a recent publication in Stroke, cerebral venous thrombosis (CVT) was found to be associated with a variant of the plasma glutathione peroxidase (GPx-3) gene (promoter haplotype H2). The observed association was strong (OR 10) and highly significant (P 0.000...
متن کاملTIMP-3 promoter gene polymorphisms in BFL.
Bird fanciers’ lung (BFL) is a form of hypersensitivity pneumonitis induced by inhalation of antigens from birds. Only a small percentage of bird fanciers will develop BFL, so it is likely that these patients have a certain genetic predisposition to the disease. Matrix metalloproteinases (MMP) are zinc enzymes responsible for the degradation of the extracellular matrix. The proteolytic activiti...
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ژورنال
عنوان ژورنال: Stroke
سال: 2007
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000252027.53766.2b